If you're using nVidia Inspector, you can now get Antialiasing (AA) in full-screen mode in older games such as FS2004 and FSX in Windows 10:
(From the A2A Simulations forum, posted by molleh)
Towards the top of the profile settings in your nVidia Inspector profile you will see a setting called "Antialiasing compatibility."
Set that to "0x004412C1 (Diablo III)" and it should work again.
Apparently many other games that run in exclusive fullscreen mode require a similar change to the antialiasing compatibility flag to have the profile settings stick like they should. In the Fall Creators Update, MS changed how fullscreen rendering works - for example, you can disable Vsync now in a borderless windowed app (such as Prepar3D!) which wasn't actually possible before because of the desktop compositor which basically forced Vsync. Apparently this new functionality wasn't tested very well on older apps/games.