Driver Profiles

Ok, I have the 56.64 drivers with my GeForce 4 Ti 4200 128MB graphics card. I have Verticle Sync enabled for global driver settings, because most games I own benefit from it or don't have an option in the game to enable it. So for Far Cry and Mafia I created profiles and set it to application controlled, because they both have the option in there set up to use it. So I am guessing this is how it has to be set to still use becasue if I turn it off, it will override the game setting will it not? Flight Sim does not benefit from Verticle Sync, at least for me anyways, so I created a profile for it and then set Verticle Sync to off. Now one of my questions is, as soon as that application is launched does that profile come into affect or do I have to go and select from the list then play the game?