Hope someone can help....

This is not specific to the QOTS but to fly a 747 across the pond one need to have a certain experience flying FS2004. So I came to you for help. My FS recently developed a very serious problem. Neither on my QOTS nor on LevelD's 767 (havent tested the rest of the planes) the various clickspots no longer seem to work.No matter what button I press on the QOTS panel selector I get no reaction. I can Shift-* the panel open but even then I have partial useability. Have any of you encountered this problem before. Does this point to a particular file I need to look at?Regards,Xander