This may or may not be related to the PMDG J41 but it is the only plane it happens with so far.  Suddenly for no apparent reason only the left mouse button stops working.  The mouse pointer changes to a cross and I can't activate any switches.  Everything else continues to work fine.  Right mouse, center wheel, and other functions work but not the left mouse.  I've tried everything I could find so far that might help.  Ctr-Alt-Del, changing zoom level, switching mouse button functions, changing to top down view, no success.  When I restart FSX all works fine and I haven't found a way to recreate the problem.  I seems random but may have to do with changing views.  I do have Ezdok but don't know if it could be related.  Has anyone encountered this?

Tony Petrowsky

You may have clicked Mouse as Yoke by mistake (easily done as it's in the context menu if you right click). That will turn the mouse cursor to a cross.

That was the cause, thanks Kevin