Hey,

Do you can advise me a very great settings for my pc specs?

RTX 2080 Ti 11Go memory
Intel Core i9-9900KF
32 GB DDR4 2666 MHz 
Two 1TB M.2 PCIe SSD
Silent Storm Cooling 3 powerful cooling system
650 Watts power supply certified 80PLUS Gold
screen 28" 3840 x 2160p

I optimized with Geforce Experience, but it's not the best setting i could wish for.

Cheers,

There isn't a one size fits all solution.

Follow this link and see what works best for you and your rig - https://forums.flightsimulator.com/t/how-to-graphics-settings-and-performance-guide-8-18-2020/132407

Thanks much!