Well I just tried a full deinstallation of everything (EZ Dok, then NGX, then FS X Acceleration Pack, then FS X). Rebooted. Then began progressive fresh install with program start at each stage and reboots before next program. I stopped after NGX reinstall and lo and behold - STILL does not work. So either EZ Dok made some registry changes that are still persistent, or this is an unrelated problem. It is not the end of the world, but certainly annoying as using the mouse wheel is so easy for MCP and Pressurization knobs vs positioning mouse and right/left clicking progressively. This seems so strange to me - it just makes no sense. Am using 2 different mice - 1 is 2.4GHZ wireless, 1 is bluetooth. Both wheels work perfectly in every other application. I suppose next step would be reinstall of Windows as if a new system - lots of work to get this functionality back...are there really no other ideas? What could be causing this? ThanksEd