Like myself, Chris has installed P3D on a fully virgin Windows set tup. I have formatted my disk(s), installed fresh version of Windows 10 and the problem persists, although less frequent than Chris as it appears, but definitely mostly during dusk/night.
It is true that P3D is capable of running a lot of add-ons without any problems, but it is also true that with plenty of add-ons things can go wrong - plenty of these on the web. What is more unusual is a virgin, default, copy showing instability for some. Whilst for some the common remedies are enough and justifiable on the basis of hardware or add-on causing instability, the case here is a completely different one - there are no possible interactions other than the P3D platform itself and the GPU.
Chris repeatedly mentioned his P3D is running on a recent/freshly installed Windows 10 OS; GPU is NOT tweaked and no other add-on installed on P3D. All very default.
@Chris, you mentioned you have tested with another 1080 card. Was it a one off test? I don't get the DXGI error on every flight. It is pretty random. Perhaps if you have flown longer with the 1080 card the problem would replicate...?