As Ark said you use the the keyboard panel marked RNAV/NAV2 to tune Nav 2, and enter the course. This displays on the CDI on the left. I spent a lot of time trying to work out if you could use Nav 2 as the source for the Autopilot, but unless I'm missing something, you can't.
There's a button on the autopilot panel marked NAV1/NAV 2 (when using 530), but that just flips from vor/loc to gps mode. To add to the confusion it doesn't change the CDI annunciation on the 530 (though it's functionally doing the same thing).
So Nav 2 works fine, but only as guidance, not for AP. Same for the 750.