This is a recurring problem and happens within minutes of preparing to take off. It happens at any airport, with any airplane and the resulting error message is the same:
Too many errors when trying to connect to simulator.
Not matching simulator interface or other SimConnect problem.
Make sure to use the right version of Little Navmap with the right simulator:
Little Navmap 32-bit: FSX and P3D
Little Navmap 64-bit: MSFS
You have to restart Little Navmap to resume.