Major wind spikes with opus and 737

Is any one else having this issue --I'm using Opus and as far as I know unless I missed something in the settings at upper cruise Fl330 as an example, not all that frequent but frequent enough the o'l girl will get a good kick in the side and she'll bank then shake a little and go back to normal . It only does it with this bird -it's the only jet I fly anyway as everything else I fly is general airplanes and don't have that problem as with then I'm always at 10,000 feet to maybe 15,000 feet. I read the recommended practices and unless I missed a setting I think she's all set right .But for sure some thing is not normal here.  The wind shifts are very abrupt and I have every thing set to default like they say to do ..