I just bought this yoke and TQ and it works great except for one nasty:  the X axis always ends up a few degrees right of center, and for some reason there is no calibration option in Windows 10 as there was in Win 7 for this product.  Moreover, the indicator in P3D's calibration routine or MSFS' wiggles slightly in its position right of center.  I tried removing the calibration settings via a routine someone made that clears calibration in the registry but it doesn't help.  To me this seems like a hardware defect.  If so, is this unique to my particular unit?  I can still send it back I believe.

I found this, which nicely fixed it, but apparently it will recur for no apparent reason.  So far I have one flight happening where it's centered, and this is P3D.  I will exit after we land, reboot and see if it stuck, then launch MSFS and repeat:

There is a well-known calibration problem with the Pro-Flight yoke that periodically causes it to drift way off-centre. As I don't know the nature of this bug I can't say if it manifests differently for different people, but my yoke would always be out to the right, not the left.

There is a temporary fix for this problem, which you can find under the support section of the Saitek web site. The fix is to delete some registry entries. It's not permanent, as the problem recurs from time to time for no clear reason. Here is the text from Saitek, which I had saved in another comment somewhere:

"To recalibrate in Windows, first remove the USB plug for your controller from the PC. Press and hold the Windows key on your keyboard and then press the letter R. This will open the Run box. Type regedit and then click ok. The Registry Editor will have a list of folders on the left hand side. Go down into the following folders in order by clicking the + next to the folder name. +HKEY_LOCAL_MACHINE (CURRENT_USER if on Vista) +System +CurrentControlSet +Control +Media Properties +Private Properties +Direct Input Delete any folder inside the Direct Input folder that begins VID_06A3. Once deleted, close the editor, then plug the USB back into the original port. Move all the axes of the controller through their full range of movement four times. Now go to Control Panel > Game Controllers > Properties to check the axes on the test screen."

MarkH