Hello, I found this post while searching on google for a solution to my problem. I have the exact same problem.I have a I7, 12gb RAM, Ati Radeon HD 5800 series rig, I run skyrim, FSX, portal, battlefield 3 etc. without no problems whatsoever and microsoft flight, in the second mission, just before or after (it varies) I near the yatch, sometimes the textures turn red and the game crashes back to desktop. I am pretty sure it isn't overheating as I even had my fan running at 100% one time and it even crashed. I tried every solution out there. Even rolled back to catalyst 12.1, switched off all the cpu cores and tried with only one. dissabled all start up programs and services, antivirus, etc.Sometimes it crashes before I land near the yatch, sometimes it crashes after I land, only once did I manage to make it to the begining of the third mission, then it crashed and when I tried to play again it actualy took me back to the first mission (As if it didnt save anything)I tried different video drivers and pretty much everything, even reinstalled the game. Windowed mode might work but I don't even want to think of that as a solution as I rather not play the game than play windowed mode.I hope a solution comes up soon.Thanks