I am running 2 x 20" in portrait with a 30" landscape for 4960 x 1600 .. with dual 480 gtx's .. it works! Now the bad news. Even with a Core i7 3.2 Ghz I have not found performance tweaks to make it run above 8 - 12 FPS. I have my settings fairly high and have tried many tweaks .. but those all seem geared for single displays or Surround mode or something. I'll try some of what I find on this thread and report back if I get it to run better.