I was having this problem of Nvidia Control Panel Settings not saving with a fresh install of new drivers. I spent forever changing all manner of things trying to figure it out. Finally, after rebooting and once again having my settings revert back to default, I opened the Geforce Experience instead of the control panel and presto. As soon as I opened the Experience window my multi-monitor and saved settings applied. I then rebooted and it has stayed set ever since. hope this helps anybody else having this issue.

I had this problem a couple of years ago and, following advice on another forum, found that uninstalling GeForce Experience solved it. There doesn't seem to be anything useful that GeForce Experience adds that can't be done better with other apps.

45 minutes ago, vortex681 said:

I had this problem a couple of years ago and, following advice on another forum, found that uninstalling GeForce Experience solved it. There doesn't seem to be anything useful that GeForce Experience adds that can't be done better with other apps.

I guess it would work that way too. I don't use it ether but it was a solution to my issue and this issue only came up after installing the latest driver.