I have used Nvidia's 3D glasses for a few years. The "2" version only differs in the monitors (brighter), not FSX's ability to use it. 3D is a lot of fun, but due to FSX programming there are a few limitations.
Night flying is largely impossible. Effects, including all the default lights, are not rendered in 3D, so the Nvidia driver can't change that. This means 2D lights that will make your eyes bug out. Landing while seeing two runways is no fun.
Some other 2D displays (glass cockpits, HUDs) will look strange as will windows for ATC or similar. These are still fully useable, just a bit odd visually.
Ghosting, 3D not quite right off center of vision, and other quirks exist for some users. This is not solely based on hardward choice (same hardware, different users, different results known to happen). I have not experienced these problems.
Multiple monitors are only fully supported with SLI and 3 identical monitors. Other setups will produce 3D on the main monitor and varying results on others depending on the particular graphics cards, drivers, day of the week, mood of the computer, et cetera. I have operated such dual monitor systems fairly happily, but sometimes 3D would just not work.