Ohh, the feeling of cranking up the computer, with all the flightplans and charts ready for your flight. Youve got it all ready to go, and FSX is up and running. 15-20 minutes++ youre roaringdown the runway, take-off is perfect. Climb init and the view is spectacular. Descent is painless, and the approach into BGI at sunset is superb! Then as you are on final approach aircraft goes nose down for no good reason at all.. was it a windshear? Perhaps, because "real world weather" is sometimes too "real"... Throttles to max and then pull back on the yoke,, nothing happens? press pause! What to do now? Pause off.. crash.. Stupid Fspassengers report says "pilot error".. And guess what? Somewheremid-flight the yoke got inverted on the elevator.. how funny, as if FSX pranked me.. Take-off went fine, pulled back on the yoke on Vr, no problems.. Final approach.. kaboom.. how the ***** does that happen by itself?? Second attempt, same route, same wheights, same everything.. In climb, pressing the right mouse button to make the menubar disappear.. FSX CTD... AAAAAAAAHHH!! ******* ohh the frustration Oh dear I hate this hobby sometimes.. all that time.. total waste! crap.. What happened?

Did the yoke get inverted, or just stop working? I've had trouble with a USB hub before, resulting in something like your story when the yoke simply disconnected in mid-air. Down went the plane, and I could do jack squat about it. It's frustrating, to be sure. I can't imagine what sort of witchcraft would result in sudden axis inversion, and I hope I never find out!

Yoke pitch axis inversion happened to me once, just the same, on final. I am pretty sure I somehow hit ctrl+Y, Mouse Flight Control On/Off, and this reversed the axis.

This used to be a problem for sure: I remeber having exactly that same problem, in FS9 - with the original CS 727, and it was wake turbulence that was the cause, and so I would suggest it may still be here in FSX. If you have ASE (REX also?) you might try turning it off, or turning the weather off completely as a test.