Hey guys I am looking for some help. I am constantly getting a ctd near my cruise altitude in both the 200 and the 300-ER. Usually if I let it be for a few minutes it unfreezes but this isn't always the case. I tried Googeling the issue with no luck. I am thinking it might be an issue with FSX.cfg. Any ideas?   

Have you applied the recommendations in the Introduction document?  There is a section of freezes and crashes and recommendations for the fsx.cfg file, pay attention to the Affinity Mask topic.

I did go through the documentation and use the recommended settings. I lowered the texture resolution and a bit and that seems to have greatly improved things.