I am setting up a flight from EGSS to LPPR using X-Plane 11.02. I have the flight loaded, validated and filed. I tune from ATIS to ClrDel. I select <callSign>ready to copy IFR Clearance and press the SayIt button. Output below.

Simulator Connected
Recognition Engine Installed
Grammars Loaded
~Ryanair Niner Six Eight ready to copy IFR Clearance
 RYANAIR Niner Six Eight Ready to Copy IFR Clearance;
Ryanair Niner Six Eight You were garbled.  Please say again.
Repeat your request.  Your phrase was not recognized. Ryanair Niner Six Eight

I do not use PTT as I don't have a mic.

Not sure what to do about this.

[EDIT] Tried the same flight in FSXSE and the same thing happened. I looked at P2A Setup and I had 'Airline Call Sign' checked, so I unchecked it and ATC responded. Weird?

There may be something "wrong" with your call sign.  Try changing the TailNumber/Flight component to just numbers and see if that will allow you to check the Airline box.

Dave

Thanks. I changed it to Boeing and all seems good now.

Also, I should have posted in the 'SayIt Errors and Issues' sticky. Apologies for that.