I have posted this on the MilViz.com KA350 support forum but thought I’d see if anyone here has run into this problem. After updating Windows 10 to 10.0.19041 Build 19041 when I try to load the KA350i I get an error message “The operating system is not presently configured to run this application.” I reinstalled the P3D Client version 4.5.14.34698 and installed latest KA350i version 1.1.38 (removed previous versions of both first). My other MilViz aircraft load fine (B55, C310R, DHC-2, PC-6). I’m stumped.

Fixed! Reply from MilViz led me to removing the AccessDatabaseEngine and reinstalling from download at https://www.microsoft.com/en-us/download/details.aspx?id=13255. 

You can also run a repair on that component as reported on TDFI discord. Either should fix it.