I started the flight from KMCO (Orlando Intl Airport) to KMIA (Miami Intl Airport).... and I requested the ATIS information so I can load the correct takeoff information into the PMDGs FMC. Once completed, I call up the tower and requested takeoff for south departure. The ATIS and the tower runway for take off was correct, however every multiplayer in the session was taking off from the opposite end of the runway! 

So my question is MSFS weather information is correct? I am more inclined to say yes because I use Navigraph Charts and it pulls the METAR information from a real world source. The heading from Navigraph METAR and MSFS 2020 ATIS is off by about 2 degrees, so that should not affect the correct runway heading for takeoff. But to see multiplayer aircraft takeoff opposite from what the tower directed is quite confusing.

Edited December 20, 20223 yr by GundamWZero

Was it AI traffic or other users flying with you?  I basically disable other users in my sim and either use no AI traffic or that provided by FSLTL.

As for your actual question...  I've noticed a lot of issues with real weather metar compared to sim weather and even how AI operates.

It's my understanding that AI traffic is very basic in this sim (but so is the ATC element).  If I were you I'd just look at the windsock when taxiing out at least to verify the wind direction (however there was a bug sometimes where the windsock will point 180 degrees the wrong way lol).

If it's correct the windsock "points" (the smaller end) to the runway end you want to depart and land.

The metar is usually your best bet and live weather will be close to it these days.  ATIS is sometimes very wrong about runway assignments and it's not uncommon for ATC to assign the exact opposite runway to what you should be using (which affects AI traffic, MP, etc.)

@ryanbatc is also correct about the windsocks.  They are a good way to verify the wind direction and strength.  I used them today to select a runway as I was at a location that had no metars, ATIS or weather reporting

Edited December 21, 20223 yr by RandallR