I don't know if the size of the screen makes any difference. What views are you using on each monitor? The 3D view takes up a lot of resources if you are using that on all of your monitors. With out using eyefinity or something that does the same thing, I don't think one computer can power more than 3 displays, at least with a single video card.For a dedicated setup like this, you need more resources, like an SDD drive, or a fast hd like the Velocoraptorhttp://www.amazon.com/Western-Digital-Velociraptor-10000-Desktop/dp/tags-on-product/B003FW9T0MI would dedicate one hd to FSX and the utilities for it, and another for the OS and everything else.For video, at least a dual video card with crossfire, or maybe a professional grade video card like Nvidia Quadro, as these are made specifically for 3D modeling.My plans are to run the instruments that output to the smaller monitors on a separate computer with WideFS and something like Project Magenta Wideview or FsXpand, and GPSout to a moving map program.I've heard that computers with more cores handle multi monitors better, so I wonder if an 8-core AMD cpu wouldn't work better. Don't skimp on the cooling either.More info on using multi networked computers:http://home.wxs.nl/~jarkest/fs/fsnetworking.html