What do you guys think? It could be a good way to use our killer setups for something else apart of FSFolding@Home

BOINC would work too. Anyone interested?

lol, I am worried to use my fsx pc for anything other than fsx as I am pushing 1.38v to get to 4.7 on my 2600k ....lol! Not sure I want to risk added degradation:), but maybe...

lol, I am worried to use my fsx pc for anything other than fsx as I am pushing 1.38v to get to 4.7 on my 2600k ....lol! Not sure I want to risk added degradation:), but maybe...

That's why so many gaming MBs these days boast two sets of BIOS's: Load the OC BIOS for FSX, load a less tweaked BIOS for [email protected],- jahman.

I have always been wondering, what is the poing of F@H, except giving away "free processor time for a good cause" and paying more for my power bill (since the CPU is drawing more power)???

That's why so many gaming MBs these days boast two sets of BIOS's: Load the OC BIOS for FSX, load a less tweaked BIOS for [email protected],- jahman.

Exactly. I have an OC profile in my BIOS for F@H, HT on, 1.326V 4.6GHz.

I have always been wondering, what is the poing of F@H, except giving away "free processor time for a good cause" and paying more for my power bill (since the CPU is drawing more power)???

That's basicaly it, yeah...ok, I guess I'll have to go solo. Even my imaginary friend refused to join my team, <_<

I have always been wondering, what is the poing of F@H, except giving away "free processor time for a good cause" and paying more for my power bill (since the CPU is drawing more power)???

Yaeh, you're right, Word Not Allowed, this folding nonsense is all a terrible waste of time and electricity!Cheers,- jahman.PS: Papers written using results obtained from Folding@Home:

1. M.R. Shirts and V. S. Pande. (2000). "Screen Savers of the World, Unite!". Science 290 (5498): 1903–1904. doi:10.1126/science.290.5498.1903. PMID 17742054.
2. Michael R. Shirts and Vijay S. Pande (2001). "Mathematical Analysis of Coupled Parallel Simulations". Physical Review Letters 86 (22): 4983–4987. Bibcode 2001PhRvL..86.4983S. doi:10.1103/PhysRevLett.86.4983. PMID 11384401.
3. Bojan Zagrovic, Eric J. Sorin and Vijay Pande (2001). "b-Hairpin Folding Simulations in Atomistic Detail Using an Implicit Solvent Model". Journal of Molecular Biology 313 (1): 151–169. doi:10.1006/jmbi.2001.5033. PMID 11601853.
4. Stefan M. Larson, Christopher D. Snow, Michael R. Shirts, and Vijay S. Pande (2002) "Folding@home and Genome@home: Using distributed computing to tackle previously intractable problems in computational biology", Stefan M. Larson, Christopher D. Snow, Michael R. Shirts, and Vijay S. Pande. Published in Computational Genomics, Richard Grant (2004), Horizon Press
5. Bojan Zagrovic, Christopher D. Snow, Michael R. Shirts, and Vijay S. Pande. (2002). "Simulation of Folding of a Small Alpha-helical Protein in Atomistic Detail using Worldwide distributed Computing". Journal of Molecular Biology 323 (5): 927–937. doi:10.1016/S0022-2836(02)00997-X. PMID 12417204.
6. Bojan Zagrovic, Christopher D. Snow, Siraj Khaliq, Michael R. Shirts, and Vijay S. Pande (2002). "Native-like Mean Structure in the Unfolded Ensemble of Small Proteins". Journal of Molecular Biology 323 (1): 153–164. doi:10.1016/S0022-2836(02)00888-4. PMID 12368107.
7. Christopher D. Snow, Bojan Zagrovic, and Vijay S. Pande (2002). "The Trp Cage: Folding Kinetics and Unfolded State Topology via Molecular Dynamics Simulations". Journal of the American Chemical Society 124 (49): 14548–14549. doi:10.1021/ja028604l. PMID 12465960.
8. Vijay S. Pande, Ian Baker, Jarrod Chapman, Sidney P. Elmer, Siraj Khaliq, Stefan M. Larson, Young Min Rhee, Michael R. Shirts, Christopher D. Snow, Eric J. Sorin, Bojan Zagrovic (2003). "Atomistic protein folding simulations on the submillisecond timescale using worldwide distributed computing". Biopolymers 68 (1): 91–109. doi:10.1002/bip.10219. PMID 12579582.
9. Young Min Rhee & Vijay S. Pande (2003). "Multiplexed-Replica Exchange Molecular Dynamics Method for Protein Folding Simulation". Biophysical Journal 84 (2): 775–786. Bibcode 2003BpJ....84..775R. doi:10.1016/S0006-3495(03)74897-8. PMC 1302658. PMID 12547762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1302658.
10. Eric J. Sorin, Young Min Rhee, Bradley J. Nakatani & Vijay S. Pande (2003). "Insights Into Nucleic Acid Conformational Dynamics from Massively Parallel Stochastic Simulations". Biophysical Journal 85 (2): 790–803. Bibcode 2003BpJ....85..790S. doi:10.1016/S0006-3495(03)74520-2. PMC 1303202. PMID 12885628. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1303202.
11. Bojan Zagrovic and Vijay S. Pande (2003). "Solvent Viscosity Dependence of the Folding Rate of a Small Protein: Distributed Computing Study". Journal of Computational Chemistry 24 (12): 1432–1436. doi:10.1002/jcc.10297. PMID 12868108.
12. Michael R. Shirts, Jed W. Pitera, William C. Swope, and Vijay S. Pande (2003). "Extremely precise free energy calculations of amino acid side chain analogs: Comparison of common molecular mechanics force fields for proteins". Journal of Chemical Physics 119 (11): 5740–5761. doi:10.1063/1.1587119.
13. Michael R. Shirts, Eric Bair, Giles Hooker, and Vijay S Pande (2003). "Equilibrium Free Energies from Nonequilibrium Measurements Using Maximum-Likelihood Methods". Physical Review Letters 91 (14): 140601. Bibcode 2003PhRvL..91n0601S. doi:10.1103/PhysRevLett.91.140601. PMID 14611511.
14. Bojan Zagrovic & Vijay S Pande (2003). "Structural correspondence between the alpha-helix and the random-flight chain resolves how unfolded proteins can have native-like properties". Nature Structural Biology 10 (11): 955–961. doi:10.1038/nsb995. PMID 14555998.
15. Eric J. Sorin, Bradley J. Nakatani, Young Min Rhee, Guha Jayachandran, V Vishal, & Vijay S Pande (2004). "Does Native State Topology Determine the RNA Folding Mechanism?". Journal of Molecular Biology 337 (4): 789–757. doi:10.1016/j.jmb.2004.02.024. PMID 15033351.
16. Christopher D. Snow, Linlin Qiu, Deguo Du, Feng Gai, Stephen J. Hagen, & Vijay S Pande (2004). "Trp zipper folding kinetics by molecular dynamics and temperature-jump spectroscopy". Proceedings of the National Academy of Sciences, USA 101 (12): 4077–4082. doi:10.1073/pnas.0305260101. PMC 384698. PMID 15020773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384698.
17. Young Min Rhee, Eric J. Sorin, Guha Jayachandran, Erik Lindahl, & Vijay S Pande (2004). "Simulations of the role of water in the protein-folding mechanism". Proceedings of the National Academy of Sciences, USA 101 (17): 6456–6461. doi:10.1073/pnas.0307898101. PMC 404066. PMID 15090647. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=404066.
18. Nina Singhal, Christopher D. Snow, and Vijay S. Pande (2004). "Using path sampling to build better Markovian state models: Predicting the folding rate and mechanism of a tryptophan zipper beta hairpin". Journal of Chemical Physics 121 (1): 415–425. doi:10.1063/1.1738647. PMID 15260562.
19. L. T. Chong, C. D. Snow, Y. M. Rhee, and V. S. Pande. (2004). "Dimerization of the p53 Oligomerization Domain: Identification of a Folding Nucleus by Molecular Dynamics Simulations". Journal of Molecular Biology 345 (4): 869–878. doi:10.1016/j.jmb.2004.10.083. PMID 15588832.
20. Eric J. Sorin, Young Min Rhee, and Vijay S. Pande (2005). "Does Water Play a Structural Role in the Folding of Small Nucleic Acids?". Biophysical Journal 88 (4): 2516–2524. doi:10.1529/biophysj.104.055087. PMC 1305348. PMID 15681648. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1305348.
21. Eric J. Sorin and Vijay S. Pande (2005). "Exploring the Helix-Coil Transition via All-atom Equilibrium Ensemble Simulations". Biophysical Journal 88 (4): 2472–2493. doi:10.1529/biophysj.104.051938. PMC 1305346. PMID 15665128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1305346.
22. Eric J. Sorin and Vijay S. Pande (2005). "Empirical Force-Field Assessment: The Interplay Between Backbone Torsions and Noncovalent Term Scaling". Journal of Computational Chemistry 26 (7): 682–690. doi:10.1002/jcc.20208. PMID 15754305.
23. C. D. Snow, E. J. Sorin, Y. M. Rhee, and V. S. Pande. (2005). "How well can simulation predict protein folding kinetics and thermodynamics?". Annual Reviews of Biophysics 34: 43–69. doi:10.1146/annurev.biophys.34.040204.144447. PMID 15869383.
24. Bojan Zagrovic, Jan Lipfert, Eric J. Sorin, Ian S. Millett, Wilfred F. van Gunsteren, Sebastian Doniach & Vijay S. Pande (2005). "Unusual compactness of a polyproline type II structure". Proceedings of the National Academy of Sciences, USA 102 (33): 11698–11703. doi:10.1073/pnas.0409693102. PMC 1187952. PMID 16085707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1187952.
25. Michael R. Shirts & Vijay S. Pande (2005). "Comparison of efficiency and bias of free energies computed by exponential averaging, the Bennett acceptance ratio, and thermodynamic integration". Journal of Chemical Physics 122 (14): 144107. doi:10.1063/1.1873592. PMID 15847516.
26. Michael R. Shirts & Vijay S. Pande (2005). "Solvation free energies of amino acid side chain analogs for common molecular mechanics water models". Journal of Chemical Physics 122 (13): 134508. doi:10.1063/1.1877132. PMID 15847482.
27. Sidney Elmer, Sanghyun Park, & Vijay S. Pande (2005). "Foldamer dynamics expressed via Markov state models. I. Explicit solvent molecular-dynamics simulations in acetonitrile, chloroform, methanol, and water". Journal of Chemical Physics 123 (11): 114902. doi:10.1063/1.2001648. PMID 16392592.
28. Sidney Elmer, Sanghyun Park, & Vijay S. Pande (2005). "Foldamer dynamics expressed via Markov state models. II. State space decomposition". Journal of Chemical Physics 123 (11): 114903. doi:10.1063/1.2008230. PMID 16392593.
29. Sanghyun Park, Randall J. Radmer, Teri E. Klein, and Vijay S. Pande (2005). "A New Set of Molecular Mechanics Parameters for Hydroxyproline and Its Use in Molecular Dynamics Simulations of Collagen-Like Peptides". Journal of Computational Chemistry 26 (15): 1612–1616. doi:10.1002/jcc.20301. PMID 16170799.
30. Hideaki Fujutani, Yoshiaki Tanida, Masakatsu Ito, Guha Jayachandran, Christopher D. Snow, Michael R. Shirts, Eric J. Sorin, and Vijay S. Pande (2005). "Direct calculation of the binding free energies of FKBP ligands using the Fujitsu BioServer massively parallel computer". Journal of Chemical Physics 123 (8): 084108. doi:10.1063/1.1999637. PMID 16164283.
31. Nina Singhal and Vijay S. Pande (2005). "Error Analysis and efficient sampling in Markovian State Models for protein folding". Journal of Chemical Physics 123 (20): 204909. doi:10.1063/1.2116947. PMID 16351319.
32. Bojan Zagrovic, Guha Jayachandran, Ian S. Millett, Sebastian Doniach and Vijay S. Pande (2005). "How large is alpha-helix in solution? Studies of the radii of gyration of helical peptides by SAXS and MD". Journal of Chemical Physics 353 (2): 232–241. doi:10.1016/j.jmb.2005.08.053. PMID 16171817.
33. Paula Petrone and Vijay S. Pande (2006). "Can conformational change be described by only a few normal modes?". Biophysical Journal 90 (5): 1583–1593. doi:10.1529/biophysj.105.070045. PMC 1367309. PMID 16361336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1367309.
34. Eric J. Sorin, Young Min Rhee, Michael R. Shirts, and Vijay S. Pande (2006). "The solvation interface is a determining factor in peptide conformational preferences". Journal of Molecular Biology 356 (1): 248–256. doi:10.1016/j.jmb.2005.11.058. PMID 16364361.
35. Eric J. Sorin and Vijay S. Pande (2006). "Nanotube confinement denatures protein helices". Journal of the American Chemical Society 128 (19): 6316–6317. doi:10.1021/ja060917j. PMID 16683786.
36. Young Min Rhee and Vijay S. Pande (2006). "On the role of chemical detail in simulating protein folding kinetics". Chemical Physics 323: 66–77. doi:10.1016/j.chemphys.2005.08.060.
37. L.T. Chong, W. C. Swope, J. W. Pitera, and V. S. Pande (2006). "A novel approach for computational alanine scanning: application to the p53 oligomerization domain". Journal of Molecular Biology 357 (3): 1039–1049. doi:10.1016/j.jmb.2005.12.083. PMID 16457841.
38. I. Suydam, C. D. Snow, V. S. Pande and S. G. Boxer. (2006). "Electric Fields at the Active Site of an Enzyme: Direct Comparison of Experiment with Theory". Science 313 (5784): 200–204. doi:10.1126/science.1127159. PMID 16840693.
39. P. Kasson, N. Kelley, N. Singhal, M. Vrjlic, A. Brunger, and V. S. Pande (2006). "Ensemble molecular dynamics yields submillisecond kinetics and intermediates of membrane fusion". Proceedings of the National Academy of Sciences, USA 103 (32): 11916–11921. doi:10.1073/pnas.0601597103. PMC 1567673. PMID 16880392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1567673.
40. Guha Jayachandran, V. Vishal, and V. S. Pande (2006). "Folding Simulations of the Villin Headpiece in All-Atom Detail". Journal of Chemical Physics 124 (16): 164902. doi:10.1063/1.2186317. PMID 16674165.
41. Guha Jayachandran, M. R. Shirts, S. Park, and V. S. Pande (2006). "Parallelized Over Parts Computation of Absolute Binding Free Energy with Docking and Molecular Dynamics". Journal of Chemical Physics 125 (8): 084901. doi:10.1063/1.2221680. PMID 16965051.
42. C. Snow and V. S. Pande (2006). "Kinetic Definition of Protein Folding Transition State Ensembles and Reaction Coordinates". Biophysical Journal 91 (1): 14–24. doi:10.1529/biophysj.105.075689. PMC 1479057. PMID 16617068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1479057.
43. S. Park, D. L. Ensign, and V. S. Pande (2006). "A Bayesian Update Method for Adaptive Weighted Sampling". Physical Review E 74 (6): 066703. doi:10.1103/PhysRevE.74.066703.
44. P. Kasson and V. S. Pande (2006). "Predicting structure and dynamics of loosely-ordered protein complexes: influenza hemagglutinin fusion peptide". PSB: 40–50. doi:10.1142/9789812772435_0005. PMID 17992744.
45. Erich Elsen, Mike Houston, V. Vishal, Eric Darve, Pat Hanrahan, and Vijay Pande (2006). "N-Body simulation on GPUs". Proceedings of the 2006 ACM/IEEE conference on Supercomputing: 188. doi:10.1145/1188455.1188649.
46. Guha Jayachandran, V. Vishal, Angel E. Garcıa and V. S. Pande (2007). "Local structure formation in simulations of two small proteins". Journal of Structural Biology 157 (3): 491–499. doi:10.1016/j.jsb.2006.10.001. PMC 1931413. PMID 17098444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1931413.
47. Adam L Beberg and Vijay S. Pande (2007). "Storage@home: Petascale Distributed Storage". IPDPS: 1. doi:10.1109/IPDPS.2007.370672.
48. J. Chodera, N. Singhal, V. S. Pande, K. Dill, and W. Swope (2007). "Automatic discovery of metastable states for the construction of Markov models of macromolecular conformational dynamics". Journal of Chemical Physics 126 (15): 155101. doi:10.1063/1.2714538. PMID 17461665.
49. D. Lucent, V. Vishal, V. S. Pande (2007). "Protein folding under confinement: a role for solvent". Proceedings of the National Academy of Sciences, USA 104 (25): 10430–10434. doi:10.1073/pnas.0608256104. PMC 1965530. PMID 17563390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1965530.
50. P. M. Kasson, A. Zomorodian, S. Park, N. Singhal, L. J. Guibas, and V. S. Pande (2007). "Persistent voids: a new structural metric for membrane fusion". Bioinformatics 23 (14): 1753–9. doi:10.1093/bioinformatics/btm250. PMID 17488753.
51. P. M. Kasson and V. S. Pande (2007). "Control of Membrane Fusion Mechanism by Lipid Composition: Predictions from Ensemble Molecular Dynamics". PLoS Computational Biology 3 (11): e220. doi:10.1371/journal.pcbi.0030220. PMC 2077900. PMID 18020701. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2077900.
52. D. L. Ensign, P. M. Kasson, and V. S. Pande (2007). "Heterogeneity Even at the Speed Limit of Folding: Large-scale Molecular Dynamics Study of a Fast-folding Variant of the Villin Headpiece". Journal of Molecular Biology 374 (3): 806–816. doi:10.1016/j.jmb.2007.09.069. PMID 17950314.
53. Alex Robertson, Edgar Luttmann, Vijay S. Pande (2007). "Effects of long-range electrostatic forces on simulated protein folding kinetics". Journal of Computational Chemistry 29 (5): 694–700. doi:10.1002/jcc.20828. PMID 17849394.
54. Nina Singhal Hinrichs and Vijay S. Pande (2007). "Calculation of the distribution of eigenvalues and eigenvectors in Markovian state models for molecular dynamics". Journal of Chemical Physics 126 (24): 244101. doi:10.1063/1.2740261. PMID 17614531.
55. Xuhui Huang, Gregory R. Bowman,and Vijay S. Pande (2008). "Convergence of folding free energy landscapes via application of enhanced sampling methods in a distributed computing environment". Journal of Chemical Physics 128 (20): 205106. doi:10.1063/1.2908251. PMC 2809694. PMID 18513049. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2809694.
56. Gregory R. Bowman, Xuhui Huang, Yuan Yao, Jian Sun, Gunnar Carlsson, Leonidas J. Guibas, and Vijay S. Pande (2008). "Structural Insight into RNA Hairpin Folding Intermediates". Journal of the American Chemical Society 130 (30): 9676–9678. doi:10.1021/ja8032857. PMC 2652247. PMID 18593120. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2652247.
57. Nicholas W. Kelley, V. Vishal, Grant A. Krafft, and Vijay S. Pande. (2008). "Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach.". Journal of Chemical Physics 129 (21): 214707. doi:10.1063/1.3010881. PMC 2674793. PMID 19063575. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2674793.
58. Paula M. Petrone, Christopher D. Snow, Del Lucent, and Vijay S. Pande (2008). "Side-chain recognition and gating in the ribosome exit tunnel". Proceedings of the National Academy of Sciences, USA 105 (43): 16549–16554. doi:10.1073/pnas.0801795105. PMC 2575457. PMID 18946046. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2575457.
59. Edgar Luttmann, Daniel L. Ensign, Vishal Vaidyanathan, Mike Houston, Noam Rimon, Jeppe Øland, Guha Jayachandran, Mark Friedrichs, Vijay S. Pande (2008). "Accelerating Molecular Dynamic Simulation on the Cell processor and PlayStation 3". Journal of Computational Chemistry 30 (2): 268–274. doi:10.1002/jcc.21054. PMID 18615421.
60. Peter M. Kasson and Vijay S. Pande (2009). "Combining Mutual Information with Structural Analysis to Screen for Functionally Important Residues in Influenza Hemagglutinin". Pacific Symposium on Biocomputing 14: 492–503. PMC 2811693. PMID 19209725. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2811693.
61. Nicholas W. Kelley, Xuhui Huang, Stephen Tam, Christoph Spiess, Judith Frydman and Vijay S. Pande (2009). "The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation". Journal of Molecular Biology 388 (5): 919–27. doi:10.1016/j.jmb.2009.01.032. PMC 2677131. PMID 19361448. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2677131.
62. M. S. Friedrichs, P. Eastman, V. Vaidyanathan, M. Houston, S. LeGrand, A. L. Beberg, D. L. Ensign, C. M. Bruns, V. S. Pande (2009). "Accelerating molecular dynamic simulation on graphics processing units". Journal of Computational Chemistry 30 (6): 864–72. doi:10.1002/jcc.21209. PMC 2724265. PMID 19191337. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2724265.
63. D. L. Ensign and V. S. Pande (2009). "The Fip35 WW Domain Folds with Structural and Mechanistic Heterogeneity in Molecular Dynamics Simulations". Biophysical Journal 96 (8): L53–55. doi:10.1016/j.bpj.2009.01.024. PMC 2718323. PMID 19383445. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2718323.
64. V. A. Voelz, E. Luttmann, G. R. Bowman, and V.S. Pande (2009). "Probing the nanosecond dynamics of a designed three-stranded beta-sheet with massively parallel molecular dynamics simulation". International Journal of Molecular Sciences 10 (3): 1013. doi:10.3390/ijms10031013. PMC 2672016. PMID 19399235. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2672016.
65. A. Beberg and V. S. Pande (2009). "Folding@home: lessons from eight years of distributed computing". IEEE International Parallel and Distributed Processing Symposium: 1–8. doi:10.1109/IPDPS.2009.5160922.
66. G. R. Bowman, X. Huang, and V. S. Pande (2009). "Using generalized ensemble simulations and Markov state models to identify conformational states". Methods 49 (2): 197–201. doi:10.1016/j.ymeth.2009.04.013. PMC 2753735. PMID 19410002. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2753735.
67. G. R. Bowman and V. S. Pande (2009). "The Roles of Entropy and Kinetics in Structure Prediction". PLoS One 4 (6): e5840. doi:10.1371/journal.pone.0005840. PMC 2688754. PMID 19513117. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2688754.
68. Peter M. Kasson, Daniel L. Ensign and Vijay S. Pande (2009). "Combining Molecular Dynamics with Bayesian Analysis To Predict and Evaluate Ligand-Binding Mutations in Influenza Hemagglutinin". Journal of the American Chemical Society 131 (32): 11338–40. doi:10.1021/ja904557w. PMC 2737089. PMID 19637916. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2737089.
69. S. Bacallado, J. Chodera, and V. Pande (2009). "Bayesian comparison of Markov models of molecular dynamics with detailed balance constraint". Journal of Chemical Physics 131 (4): 045106. doi:10.1063/1.3192309. PMC 2730706. PMID 19655927. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2730706.
70. Vincent A. Voelz, Gregory R. Bowman, Kyle Beauchamp and Vijay S. Pande (2010). "Molecular Simulation of ab Initio Protein Folding for a Millisecond Folder NTL9(1−39)". Journal of the American Chemical Society 132 (5): 1526–1528. doi:10.1021/ja9090353. PMC 2835335. PMID 20070076. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2835335.
71. P. M. Kasson, E. Lindahl, and V. S. Pande (2010). "Atomic-Resolution Simulations Predict a Transition State for Vesicle Fusion Defined by Contact of a Few Lipid Tails". PLoS Computational Biology 6 (6): e1000829. doi:10.1371/journal.pcbi.1000829. PMC 2891707. PMID 20585620. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2891707.
72. G. R. Bowman and V. S. Pande (2010). "Protein folded states are kinetic hubs". Proceedings of the National Academy of Sciences, USA 107 (24): 10890–10895. doi:10.1073/pnas.1003962107. PMC 2890711. PMID 20534497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2890711.
73. V. S. Pande (2010). "A simple theory of protein folding kinetics". Physical Review Letters.
74. EJ Thompson, AJ DePaul, SS Patel & EJ Sorin (2010). "Evaluating Molecular Mechanical Potentials for Helical Peptides and Proteins.". PLoS ONE 5 (4): e10056. doi:10.1371/journal.pone.0010056.g001. PMC 2850926. PMID 20418937. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2850926.
75. AJ DePaul, EJ Thompson, SS Patel, K Haldeman & EJ Sorin (2010). "Equilibrium conformational dynamics in an RNA tetraloop from massively parallel molecular dynamics". Nucleic Acids Research 38 (14): 4856–4867. doi:10.1093/nar/gkq134. PMC 2919701. PMID 20223768. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2919701.
76. Peter M. Kasson, Erik Lindahl, and Vijay S. Pande (2011). "Water Ordering at Membrane Interfaces Controls Fusion Dynamics". Journal of the American Chemical Society. doi:10.1021/ja200310d.

Someday you might avoid getting folded into a coffin thanks to the research made possible by the CPU time donated by volunteers to Folding@Home.

Yeah, okay... It's just not my thing, sorry. I'll get folded into a coffin earlier or later...

As it happens, AVSIM had a "team" for a similar distributed computational project about -what was it now? - ten years or so ago. :Applause: I know that I had it set up to run in the background by four of my network's servers for almost four years, only taking it down when the project was finally completed.Genome@Home project it was...Phase 2 began November 12, 2001. Because of this, less than three years were needed to complete almost 20 thousand CPU years of work. :Applause:

April 2, 2003The scientific work for which this client was built has now been accomplished. The Genome@home worldwide protein design cluster has, to date, used almost 20,000 donated CPU-years to calculate over 6 million new protein sequences. The scientific work behind the G@h 0.99 client, consisting of nine distinct phases, has already resulted in four major scientific publications and produced novel insight into fundamental mysteries behind the protein structure-sequence relationship. The 0.99 client has also allowed us to pursue unprecedented work in studies of protein evolution and protein structure prediction. Much of our work in the short-term will include continued analysis, interpretation, and publication of the data that we've collected from the 0.99 client.

As it happens, AVSIM had a "team" for a similar distributed computational project about -what was it now? - ten years or so ago. :Applause: I know that I had it set up to run in the background by four of my network's servers for almost four years, only taking it down when the project was finally completed.Genome@Home project it was...Phase 2 began November 12, 2001. Because of this, less than three years were needed to complete almost 20 thousand CPU years of work. :Applause:

That's awesome Bill :smile:I can see Genome@Home was also a Vijay Pande project. Well, I'm a F@H lone rider ATM, but if anyone is interested in a revival of Avsim & G@H, I'm all for it. No competitions or anything like that, just for fun and to help investigations

Genome@home was, ahem, folded into Folding@Home, and the work has since been completed.Servers now contribute little as the real power is in the GPUs and Sony PS3's. Currently F@H runs sustained of 10 PetaFLOPs, i.e. 4x the fastest non-distributed computer in the World (The chinese Tianhe 1A at 2.5 PetaFLOPs with 2,168 nVidia Fermi 460 GTX GPUs).Current F@H stats show a total of just under 10 (x86 equivalent) PetaFLOPs, with nVidia, ATI and PS3 outputs accounting for 60%, 20% and 15% of total output, respectively.Those interested refer to the F@H Main Page.Take a look at

, as discovered by F@H.Side track:Those interested in molecular biology, see complex molecules (rotating molecular motors!)

(ATP - Adenosine Triphosphate) in the cell's mitochondria. Most folks don't realize the cells in their body generate their own bodyweight in TPA every single day! (You weigh 180 lbs, you generate 180 lbs of TPA ever 24 hrs.) Heck, most folks don't even know TPA exists.There's a new high-tech field of study popping-up which is visualizing cell prcesses at the molecular level. F@H makes this possible by modelling the molecular structure.Back to FlightSimming:Someday the awesome power of GPUs will be used to sim airflow over wings and control surfaces to get very, very accurate sim aerodynamics.Cheers,- jahman.

Yeah, CUDA rocks thanks for the info jahman, good readEDIT: I'm TPA = Top Poster in Avsim :P

F@H is a great stress-testing application. I'm a member of one of the top 20 folding teams in the world (Rage3D, team 64) and we have had one of the single highest contributing members in the program's history folding for us under a couple different user names. He runs F@H as a burn-in utility whenever he rolls out new systems at the University he works for. He pushes the program out over the network to selected PCs and lets them run for a few weeks at a time to make sure they're "production ready". If you want to know if your system is stable, forget about apps like Prime 95, OCCT, and IBT - run F@H for a week or two and if your system doesn't reboot, lock up, or produce corrupt work units during that time frame then you can rest assured it is stable. Unlike the aforementioned applications, F@H can stress large amounts of RAM in addition to the CPU itself (even GPU, if you choose to run the GPU client also).

F@H is one of the ingredients necessary to trigger "The Singularity" where technology will allow humans to control their chromosomes and their genetic destiny and outsmart natural evolution (we hope...), according to Ray Kurzweil. If you are interested you can even take courses at Singularity University, located where else but in a very, very cool place: NASA's Ames Research Center at Moffett Field (KNUQ). What a collection of brainiacs you'll find there!If you haven't done so already, I recomment you fly there for a looksee of one of the World's largest hangars built to house zeppelins. Best viewed if you have MegaSceneryEarth's California State PhotoReal installed (or at least "Tile Numer 9") Fly in on a period DC-3 and be awed.Hangar 1 at NASA Ames/Moffett Field (KNUQ):Why build a scale model aircraft for wind tunnel testing is you can fit the full-scale aircraft in the Wind tunnel?Cheers,- jahman.