I use FSX and also the Saitek Yoke Pro. I did nothing in FSUIPC even having the full version. I used SPAD to get beter driver for Saitek with W10, but you have to reinstall the switch panel, the pedal and the instrument panel with the original drivers of Saitek. That works after very good for FSX with W10.
The radio works too if you configure correctly the PMDG radio, and I use only from Saitek the spoiler, the reverse, the trim, the brakes, the gateaway, the ezdock camera, the pushback, or from PMDG or FSX when GSX insn't avaible, the quake is always correct and the CRS also (just for info), but with no use. Don't try the Saitek A/P, HDG, IAS, VS and ALT. it doesn't work, but use only the PMDG A/P.
You restart your PC for the planes of FSX (P3D) and Saitek works correctly.
Good Flight