I plan on getting a Honeycomb Yoke and Throttle Quadrant for MSFS and would like to know if I'll be able to fly and operate my planes without a dedicated rudder pedals? I plan to get that later down the road.

Autorudder will be your friend.

Hard work and not very realistic but yes, you can...

 

I would say given you've gone to the trouble of splashing out on Honeycomb Yoke and Throttle a little bit extra would raise the bar.

 

You can pick up a cheap pair of pedals on ebay..They add so much to the experience of as real as it gets..

Would recommend Milan Flight Gear for when you decide to get the pedals. Personally I used flight sims without rudder pedals for quite a while before I finally got them and would say that having the pedals makes a big difference. Rudder assist will help you make coordinated turns which is fine but sometimes you need to apply rudder and ailerons in a way that isn't a coordinated turn (such as during crosswind landings etc). It's definitely worth getting. 

Rudders would be very good but not strictly necessary. Some alternatives:

Joystick (unmap everything, assign rudder to either the roll axis or yaw axis)
Yoke (map to hold a button+roll axis or a few switches+roll axis to act as a rudder-- excellent for ground steering, not so good for takeoff/landing)
Throttle (map it to a throttle axis, so 100% power turns one direction and 0% power turns the other direction)

I use a combination of joystick (twist/yaw axis) and yoke (hold a button+roll axis). The joystick also controls where I'm looking as the hat switch lets me look left/right. A button or two is mapped to also reset the camera. The yoke's hat switch is for preset quick-views and down-down-Left/Right for instrument/panel views. The keyboard's arrows lets me shift the camera left/right/up/down from where the camera's looking.

I have tried everything over the years and now prefer just a joystick with twist action for the rudder.  Plus my wife says I look silly pretending behind yokes and pedals etc!  Maybe because I am a real-life recreational pilot I get enough of the real thing that way?  Cheers.