So with these new nvidia drivers, I was having issue playing Flight in surround. I could get the game to maximize to my 5760x1080+ resolution, but anytime I would click in game, the game would minimize and I would be at my desktop.
What appears to be happening is the game was not taking over control of the mouse.
After some messing around I realized this issue is tied to the new Nvidia environment control - now nvidia will maximize a window to a single screen, even if you are in surround mode (which is a great improvement!). However, with this enabled you cannot use your mouse in game.
To fix this with the nvidia control panel open, on the top menu click Desktop > Surround Displays > Maximize Window Across All Displays (Make sure this is checked).
Hope that helps someone with the same issue!