I am happy to report that my connection issue which was identical to so many others was fixed by the latest VAinterface update 2.26. I use the PMDG 777 and find that powering up the airplane first with either APU or GPU, letting the avionics settle after initial bootup (ADIRU not included in this, just the initial power up) and then connecting to VAinterface it works perfectly.
I also want to add that I deleted the previous entry in the windows firewall for the old VAinterface version, and manually added the new one prior to using it in P3D v4.2. Not sure if that had any effect but I suggest doing that along with making sure it runs as administrator and is unaffected by anti-virus software. Hope this helps! Thanks VA for working on this update!
Zach
