You might want to check at the org, there are linux specific forums. It seems quite a few different distros are used, probably Mint, Debian and Ubuntu are the most popular. I have been running X-Plane 11 (and previously 10) on Antergos without problems, using a GTX1070 and nVidia 396.24 drivers.
Most users report as good or better performance on linux compared to win. There are some developer considerations. The FF 320 Ultimate is currently not supported on linux, nor are any of the products from X-Aviation. The rest of the Flight Factor a/c run under linux, I have the 767 and 752, both very good models. Best Airbus, IMHO, is the Toliss A319.
Hope this helps,
(Also: IXEG 737 and X-Enviro weather addons not supported)