I have flown without failures so far but would like to practice one. Maybe start of with an inflight cargo fire and land at the nearest airport. Perhaps from EGLL-LSZH with the alt somewhere in Belgium as I will set the failure over there? or even KSFo-KIAD and set the failure just after takeoff and land at KLAS?

Your post contains two question marks, but no actual question. What would you like to know?

I was just looking for ideas for the flight. For example what is an easy failure?  i guess a cargo fire is easier to deal with then a engine out. Also some ideas for routes.

Doesn't matter what failure you choose or  the route you pick practise makes perfect, if you fail the first attempt  try it  again

NGX, ETOPS 180 flight, in the middle of no where, dual engine failure

 

Go!

NGX, ETOPS 180 flight, in the middle of no where, dual engine failure

 

Go!

why not  go  for all the systems  at once

I would suggest Engine Out at V1, this one definitely requires you to be in your best. Read the procedures and know them by heart before trying it, you won't have time to think after it happens.

A cabin depressurisation at cruise altitude is guaranteed to grab your attention as well, if only for that infernal cabin altitude horn (which thankfully can be silenced).

 

(which thankfully can be silenced)

 

...or is that just from the hypoxia?

(haha)

Just remember that if you have a cargo fire - you want to be on the ground in a maximum of 15 minutes - in reality your chances of survival greatly decrease over this time. As this is not modeled (as far as I know) try running against the clock instead!

I would think that a cargo fire is up there with one of the scariest things you can imagine on any sort of large transport aircraft!

I think it's much harder to work through emergency situations on a PC-based application such as MSFS than even in a fixed-base simulator. The reason being that using mouse clicks and changing the point of view with the HAT switch is slow and time-consuming whereas a simulator allows quick and accurate actions. This is even more noticeable in time-sensitive emergencies and the reason why I have (so far) never flown with any failures on at all.