About 20 times as safe as a DC-8 and two and a bit times as safe as a 744, according to page 20 of this pdf: http://www.boeing.com/news/techissues/pdf/statsum.pdf. Though it's worth bearing in mind that other things (ATC, training of pilots, crew resource management) have also seen a lot of development between when the DC-8 first flew and when the T7 first flew, so it's not just down to aircraft type. Also these numbers don't include either of the Malaysian crashes.
This also has some interesting stats: http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_06.pdf. 26,000 people died of falls in 2011, 34,677 died in motor vehicle accidents, and 'only' 1,467 in 'Water, air and space, and other and unspecified transport accidents and their sequelae'
The Israeli company Elbit sells a system designed to protect airliners from shoulder launched missiles. I think it's been fitted to El Al planes: https://www.elbitsystems.com/elbitmain/area-in2.asp?parent=399&num=400&num2=400
Won't help much against a radar guided missile of course.